Niacin studies datasheet - 2019 Update

Here is a summary list of Niacin studies showing its effect on human performance.

 

Last updated: 14 May 2019 

 

Human studies  

 

Cognitive performance

 

  • A study of 3136 adults found that cumulative total intake of niacin was significantly associated with increased psychomotor speed and executive function (3.92 more digits on the Digit Symbol Substitution Test and 1.89 points lower interference score on the Stroop test) (Study)

 

Inflammation

 

  • A 2018 study reported that lower dose of niacin in Parkinson's Disease (PD) patients may affect macrophage polarization from M1 (pro-inflammatory) to M2 (counter-inflammatory) profile, accompanied by improved quality of life assessments in patients. Low dose niacin supplementation may be beneficial in PD, boosting anti-inflammatory processes and suppressing inflammation (Study)

  • A study of 72 patients with osteoarthritis found that niacinamide (niacin derivative) improved the global impact of osteoarthritis, improved joint flexibility, reduced inflammation, and allowed for reduction in standard anti-inflammatory medications when compared to placebo (Study)

 

 

Animal studies  

 

  • A study exploring the effect of niacin in a murine (rat) model concluded that niacin was effective against iodoacetamide-induced colitis through ameliorating pathologic angiogenesis and inflammatory changes in a GPR109A-dependent manner (Study)

  • Another murine study stated that niacin pretreatment protects lungs against ischemia and reperfusion-induced barrier function impairment through the activation of SIRT1 and reduced pulmonary oxidative stress and lung inflammation (Study)

  • A study showed that niacin pretreatment reduced pancreatic ischemia and reperfusion-induced pancreatic and lung injury and protected against pulmonary barrier function impairment, which was associated with niacin's antioxidative and anti-inflammatory activity and its capacity to increase SIRT1 mRNA expression (Study

 

 

In Vitro studies 

 

  •  A 2019 study demonstrated that nicotinamide riboside (Niacin's form) attenuated hepatic inflammation and increased levels of mitochondrial markers in hepatocytes (Study)

 

 

Niacin food sources 

 

  • Liver (Beef, chicken)
  • Chicken breast 
  • Tuna
  • Turkey 
  • Salmon
  • Pork
  • Anchovies
  • Ground beef 
  • Peanuts
  • Green peas
  • Avocado
  • Brown rice
  • Whole wheat
  • Mushrooms 
  • Green peas
  • Potatoes 
  • Sunflower seeds 

 

 

For more information about food sources visit https://ndb.nal.usda.gov/ndb/

For more Niacin studies visit https://www.ncbi.nlm.nih.gov/pubmed/?term=niacin

 

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