The effects of Ginkgo biloba extract on cognitive functions in aged female rats: the role of oxidative stress and brain-derived neurotrophic factor
Belviranlı M, Okudan N
|Study Model||Animal - Rat|
I’m surprised that in 2018 access to knowledge is still limited, with many scientific articles hidden behind expensive subscriptions. I’m saying that because I think you might be interested in an article written by Belviranli. The abstract is free and available here. The full article is going to cost you some money (unfortunately).
In this article, rats were treated for 30 days with a Ginkgo biloba extract, followed by a series of behavioural and molecular tests. The authors pointed out that locomotor activity and anxiety levels were lower in the aged rats.
What’s interesting here is that Ginkgo-treated animals performed better in the Morris water maze test. The principle of that test is simple – a test animal is placed in a circular pool filled with water and is required to find an invisible or visible platform that allows it to escape the water by using various cues.
In addition, the treated animals had higher levels of BDNF in their blood plasma and lower levels of oxidative damage markers. BDNF levels are of particular interest to me as this protein supports the survival of existing neurons, and promotes the growth and differentiation of new neurons and synapses. More BDNF, more neurons, more connections, smarter you? Sounds good to me for sure.
Dr Bart Alright