Caffeine studies datasheet - 2019 update

Here is a summary list of caffeine studies showing caffeine's effect on cognitive functions.


Last updated: 14 May 2019 






  • In a study of 68 U.S. Navy SEAL trainees under stress (72 hours of sleep deprivation and continuous exposure to other stressors) caffeine (200 and 300 mg) significantly improved visual vigilance, choice reaction time, repeated acquisition, self-reported fatigue and sleepiness with the greatest effects on tests of vigilance, reaction time, and alertness (Study)

  • In a study of 48 subjects caffeine (4mg/kg) improved performance on a sustained attention task, the logical reasoning task and semantic memory task. Subjects given caffeine also reported greater alertness and feelings of well-being (Study)

  • In a study of 41 males and 41 females, aged 45-60, administration of a 60 mg caffeine dose resulted in a significant improvement in sustained attention compared with the placebo. Also a significantly improved peak saccadic velocity and reaction time performance was found, and decreased error rate. Significantly increased feelings of alertness, contentment and overall mood after caffeine treatment compared with placebo were observed (Study)

  • Another study of caffeine (2mg/kg) showed that ingestion of caffeine was associated with faster simple reaction time, fewer long responses, greater detection of targets in the cognitive vigilance task, and faster encoding of new information (Study)

  • In a study of 48 healthy adults caffeine (250mg) increased self-rated alertness and jitteriness and blood pressure (Study)

  • In a study of 80 young adult males early morning caffeine significantly antagonized hypnotic-induced drowsiness caused by flurazepam/triazolam and enhanced alertness in the subjects who received bed-time placebo (Study)

  • A literature review of double-blind placebo controlled studies that assessed acute effects of caffeine on attention tasks in healthy adult volunteers found that caffeine improves performance on simple and complex attention tasks, and affects the alerting, and executive control networks (Study)




  • In a study comparing effects of caffeine and breakfast, caffeine (4 mg/kg) improved performance on the semantic memory, logical reasoning, free recall and recognition memory tasks (Study)

  • Another study showed that habitual caffeine usage systematically affected tonic arousal (skin conductance level) and improved recall task performance. Acute caffeine ingestion increased phasic arousal (skin conductance response amplitude) and reduced habituation rates (Study




    • A study investigating effects of 2 doses of caffeine (75 mg and 150 mg) in healthy people showed improvements in attention, problem solving and delayed recall. For mood, there were statistically significant increase in clearheadedness, happiness and calmness and decreases in tenseness (Study)

    • In a study comparing caffeine (100 mg), tryptophan (500 mg), and tyrosine (500 mg) in 60 volunteers caffeine significantly increased scores for wakefulness, vigor, clarity of mind, energy, feeling full of ideas, feeling full of go and feeling efficient. Caffeine was also ranked as the most stimulating treatment (Study)



       Caffeine food sources


      • Coffee 
      • Matcha green tea
      • Green tea
      • Cocoa beans (chocolate, hot chocolate, chocolate ice cream)
      • Black tea
      • Yerba mate
      • (Caffeinated) soft drinks
      • Energy drinks 
      • Guarana berry
      • Kombucha



      For more information about food sources visit

      For more Caffeine studies visit

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