Acetyl-L-Carnitine studies datasheet - 2019 Update

Here is a summary list of Acetyl-L-Carnitine studies showing its effect on cognitive functions.

 

Last updated: 29/04/19 

 

Human studies  

 

Cognitive performance 

 

  • A study investigating efficacy Acetyl-L-Carnitine in mild cognitive impairment  and mild Alzheimer's disease showed beneficial effects on both clinical scales and psychometric tests (Study

  • A study of 12 healthy adults concluded that L-carnitine (2g) increases activities of antioxidant enzymes and the total antioxidant capacity in healthy subjects. It may be useful as a supplementary therapy for chronic illnesses involving excessive oxidative stress (Study)

 

Fatigue

 

  • A study of 96 aged adults (71-77 years old) showed that administering Acetyl-L-Carnitine may reduce both physical and mental fatigue in elderly and improves both the cognitive status and physical functions (Study)

  • Another study showed that Acetyl-L-Carnitine had beneficial effect on mental fatigue and attention concentration in chronic fatigue patients (Study)

 

  

Animal studies 

 

  • A study demonstrated that pretreatment with Acetyl-L-Carnitine exerts effective neuroprotection against the MDMA-induced neurotoxicity. The results indicate potential benefits of Acetyl-L-Carnitine application in the prevention and treatment of neurodegenerative disorders (Study)

  • Dietary supplementation with Acetyl-L-Carnitine (ALCAR) and/or R-alpa-lipoic acid (LA) improved spatial and temporal memory. The results suggest that feeding ALCAR and LA to old rats improves performance on memory tasks by lowering oxidative damage and improving mitochondrial function (Study

 

 

In Vitro studies 

 

  • Acetyl-L-Carnitine prevented mitochondrial membrane protein damage and decreased membrane potential after ethanol exposure. The findings suggest the counteracting mechanisms of oxidants and antioxidants during alcohol-induced oxidative stress at the blood-brain barrier. The presence of enzymatic stabilizers favors the ROS-neutralizing antioxidant redox of the BBB, suggesting an underlying protective mechanism of NO for brain vascular tone and vasodilation (Study)
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